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LYZ Antibody / Lysozyme C

CAT: 0800-V9674SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V9674SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Lysozyme is an enzyme, commonly referred to as the body s own antibiotic since it kills bacteria. Natural substrate of lysozyme is the bacterial cell wall peptidoglycan (cleaving the beta[1-4] glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine) . Lysozyme is one of the antimicrobial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. The protein has antibacterial activity against a number of bacterial species. Lysozyme is synthesized predominantly in reactive histiocytes rather than in resting, unstimulated phagocytes. This antibody labels myeloid cells, histiocytes, granulocytes, macrophages and monocytes. It is helpful in the identification of myeloid or monocytic nature of acute leukemia.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P61626
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 18-147 was used as the immunogen for the LYZ antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
LYZ/3947
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the LYZ antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This LYZ antibody is available for research use only.
Storage Conditions
Aliquot the LYZ antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the LYZ antibody should be determined by the researcher.
Location
Secreted
Image Legend
IHC staining of FFPE human spleen tissue with LYZ antibody (clone LYZ/3947) . Negative control inset: PBS instead of primary antibody to control for secondary binding. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P61626

Lysozyme C

LYSC_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P61626
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
LYZ
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.2.1.17
Processing
Precursor
Secondary accessions
P00695, Q13170, Q9UCF8
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Cellular component

AmyloidSecreted

Disease

AmyloidosisDisease variant

Molecular function

AntimicrobialBacteriolytic enzymeGlycosidaseHydrolase

PTM

Disulfide bond

Domain

Signal

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