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Recombinant Vinculin Antibody

CAT: 0800-V9615SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V9615SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Focal adhesions are identified as areas within the plasma membrane of tissue culture cells that adhere tightly to the underlying substrate. In vivo, these regions are involved in the adhesion of cells to the extracellular matrix. Paxillin and vinculin are cytoskeletal, focal adhesion proteins that are components of a protein complex which links the Actin network to the plasma membrane. Vinculin binding sites have been identified on other cytoskeletal proteins, including Talin and -Actinin has been shown to link Actin to integrins in the plasma membrane through interactions with the vinculin and Talin complex or by a direct interaction with integrin.
CAS Number
9000-83-3
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P18206
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
A portion of amino acids 174-322 was used as the immunogen for the recombinant Vinculin antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG
Clone
VCL/7091R
Type
Recombinant
Applications
WB, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the recombinant Vinculin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This recombinant Vinculin antibody is available for research use only.
Storage Conditions
Aliquot the recombinant Vinculin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the recombinant Vinculin antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
IHC staining of FFPE human pancreas with recombinant Vinculin antibody (clone VCL/7091R) at 2ug/ml. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P18206

Vinculin

VINC_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P18206
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
VCL
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q16450, Q5SWX2, Q7Z3B8, Q8IXU7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationLipoproteinPalmitatePhosphoprotein

Molecular function

Actin-binding

Coding sequence diversity

Alternative splicing

Disease

CardiomyopathyDisease variant

Biological process

Cell adhesion

Cellular component

Cell junctionCell membraneCell projectionCytoplasmCytoskeletonMembrane

Domain

Repeat

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