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INDOL1 Antibody / IDO2

CAT: 0800-V9591-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V9591-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IDO2 is a presumptive immunomodulatory gene based on its close structural relationship to IDO1 and its expression in a variety of antigen-presenting cell types. Both IDO1 and IDO2 will catabolize tryptophan to kynurenine. Biochemical studies indicate that both enzymes are similarly robust in catabolic activity, although the in vitro conditions required for IDO2 to manifest the same level of activity differ somewhat from IDO1. However, whether IDO2 is active as a tryptophan catabolizing enzyme in human dendritic cells has been disputed. Further work is needed to conclusively determine that IDO1 and IDO2 are similar in their preference for substrates and reaction pathways to generate product. A non-redundant function for IDO2 relative to IDO1 is suggested by their rather distinct expression patterns and response to extracellular stimuli.
CAS Number
9007-83-4
Specifications
ELISA (order BSA-free format for coating), Immunohistochemistry (FFPE) : 1-2 µg/mL, Western blot: 2-4 µg/mL
UniProt
Q6ZQW0
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 200-350 was used as the immunogen for the INDOL1 antibody.
Clonality
Monoclonal
Isotype
IgG κ
Clone
IDO2/2638
Applications
ELISA, IHC-P, WB
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the INDOL1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This INDOL1 antibody is available for research use only.
Storage Conditions
Aliquot the INDOL1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the INDOL1 antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
Analysis of HuProt (TM) microarray containing more than 19,000 full-length human proteins using INDOL1 antibody (clone IDO2/2638) . These results demonstrate the foremost specificity of the IDO2/2638 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.

UniProtKB · Q6ZQW0

Indoleamine 2,3-dioxygenase 2

I23O2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q6ZQW0
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IDO2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IDO-2
EC number
1.13.11.-
Processing
—
Secondary accessions
A4UD41, F5H5G0
Protein keywords

Coding sequence diversity

Alternative splicing

Molecular function

DioxygenaseOxidoreductase

Ligand

HemeIronMetal-binding

Biological process

ImmunityTryptophan catabolism

Technical term

Proteomics identificationReference proteome

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