Reelin Antibody / RELN

CAT: 0800-V9527-100UGSize: 100 µgDry Ice: NoHazardous: No

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CAT#:0800-V9527-100UGSize:100 µg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Reelin (or Reln) is a large glycoprotein that is secreted by Cajal-Retzius cells in the forebrain and by granule neurons in the cerebellum. Reelin was shown to be mutated in reeler mice, a mutation that is associated with widespread disruption of laminated regions of the brain, leading to impaired motor coordination, tremors and ataxia. Reelin protein expression is complex and changes throughout development. Reelin appears to function upstream of Dab1, in a signaling pathway that controls cell positioning in the developing brain, and is also thought to be a direct effector of the neurotrophin BDNF.

CAS Number

9007-83-4

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL

UniProt

P78509

Host

Mouse

Reactivity

Human

Immunogen

A portion of amino acids 1796-2115 was used as the immunogen for the Reelin antibody.

Clonality

Monoclonal

Isotype

IgG2b

Clone

RELN/4498

Applications

IHC-P

Purity

Protein A/G affinity

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Reconstitution

Aliquot the Reelin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This Reelin antibody is available for research use only.

Storage Conditions

Aliquot the Reelin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Applications Notes

Optimal dilution of the Reelin antibody should be determined by the researcher.

Location

Cytoplasm

Image Legend

IHC staining of FFPE human kidney tissue with Reelin antibody (clone RELN/4498) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P78509

Reelin

RELN_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P78509
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: RELN
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 3.4.21.-
Processing: Precursor
Secondary accessions: A4D0P9, A4D0Q0, Q86UJ0, Q86UJ8, Q8NDV0, Q9UDQ2

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-bindingZinc

Biological process

Cell adhesion

Molecular function

Developmental proteinHydrolaseProteaseSerine protease

Disease

Disease variantEpilepsyLissencephaly

PTM

Disulfide bondGlycoprotein

Domain

EGF-like domainRepeatSignal

Cellular component

Extracellular matrixSecreted

Product Datasheet

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abx174351-01	Reelin (RELN) Antibody
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abx273403-01	Reelin (RELN) Antibody (Biotin)
CAU34110-01	Reelin (RELN) Monoclonal Antibody
CAU23878-01	Reelin (RELN) Polyclonal Antibody
TRV-003342-01	Polyclonal Antibody to Reelin (RELN)
TRV-001771-01	Monoclonal Antibody to Reelin (RELN)
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