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Recombinant Cdc20 Antibody

CAT: 0800-V9446-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V9446-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Required for full ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) and may confer substrate specificity upon the complex. Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates. The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation. [UniProt]
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
Q12834
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant human Cdc20 protein was used as the immunogen for the recombinant Cdc20 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
CDC20/7026R
Type
Recombinant
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the recombinant Cdc20 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This recombinant Cdc20 antibody is available for research use only.
Storage Conditions
Aliquot the recombinant Cdc20 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the recombinant Cdc20 antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
IHC staining of FFPE human kidney tissue with recombinant Cdc20 antibody CDC20/7026R) at 2ug/ml. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · Q12834

Cell division cycle protein 20 homolog

CDC20_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q12834
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CDC20
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2R6Z6, D3DPJ1, Q5JUY4, Q9BW56, Q9UQI9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Biological process

Cell cycleCell divisionDifferentiationMitosisNeurogenesisUbl conjugation pathway

Cellular component

CentromereChromosomeCytoplasmCytoskeletonKinetochore

Disease

Disease variant

Domain

RepeatWD repeat
Product Datasheet
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