Physcion-d3

• Description:

  Physcion-d3 (Parietin-d3) is the deuterium labeled Physcion (HY-N0108) . Physcion acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively. Physcion exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects[1][2][3].

• Product Name Alternative:

  Parietin-d3; Rheochrysidin-d3

• UNSPSC:

  12352005

• Target:

  Bacterial; Isotope-Labeled Compounds

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Anti-infection; Others

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Infection; Inflammation/Immunology

• Purity:

  99.82

• Solubility:

  DMF : 1mg/mL (ultrasonic) |DMSO : 3.33mg/mL (ultrasonic; warming; adjust pH to 9 with NaOH; heat to 60°C) |THF : 2.5mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C1C2=CC(OC([2H])([2H])[2H])=CC(O)=C2C(C3=C(O)C=C(C)C=C31)=O

• Molecular Formula:

  C16H9D3O5

• Molecular Weight:

  287.28

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Lin R, et al. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17 (11) :1484-96.|[3]Pang MJ, et al. Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma. Acta Pharmacol Sin. 2016 Dec;37 (12) :1623-1640.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  [1215751-27-1]