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Physcion

CAT: 0804-HY-N0108-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N0108-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Physcion (Parietin), an anthraquinone derivative derived from the traditional Chinese medicine rhubarb, is an effective oral active 6-phosphogluconate dehydrogenase inhibitor with blood-brain barrier permeability, with IC50 and Kd values of 38.5 μM and 26.0 μM, respectively. Additionally, Physcion is an inhibitor of the bTLR4/NF-κB signaling pathway, exhibiting anti-inflammatory, antibacterial, and anticancer effects, and can induce Apoptosis and Autophagy in cancer cells[1][2][3][4][5].
CAS Number
521-61-9
Product Name Alternative
Parietin; Rheochrysidin
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Antibiotic; Apoptosis; Autophagy; Bacterial; NF-κB; Toll-like Receptor (TLR)
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Autophagy; Immunology/Inflammation; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Physcion.html
Concentration
10mM
Purity
99.40
Solubility
DMF : 1 mg/mL (ultrasonic) |Ethanol : < 1 mg/mL|THF : 2.5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=C(C=C(C)C=C2O)C(C3=CC(OC)=CC(O)=C13)=O
Molecular Formula
C16H12O5
Molecular Weight
284.26
Precautions
H302, H315, H319, H335
References & Citations
[1]Lin R, et al. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17 (11) :1484-96.|[2]Pang MJ, et al. Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma. Acta Pharmacol Sin. 2016 Dec;37 (12) :1623-1640.|[3]Dong X, et al. Physcion Protects Rats Against Cerebral Ischemia-Reperfusion Injury via Inhibition of TLR4/NF-kB Signaling Pathway. Drug Des Devel Ther. 2021 Jan 25;15:277-287.|[4]Liu X, et al. Physcion, a novel anthraquinone derivative against Chlamydia psittaci infection. Vet Microbiol. 2023 Apr;279:109664. doi: 10.1016/j.vetmic.2023.109664.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
TLR4

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