Physcion (Standard)

• Description:

  Physcion (Standard) is the analytical standard of Physcion. This product is intended for research and analytical applications. Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively[1][2]. Physcion (Parietin) exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects[2].

• Product Name Alternative:

  Parietin (Standard) ; Rheochrysidin (Standard)

• UNSPSC:

  12352005

• Target:

  Bacterial; Reference Standards

• Type:

  Reference Standards

• Related Pathways:

  Anti-infection; Others

• Field of Research:

  Cancer; Infection; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/physcion-standard.html

• Smiles:

  O=C1C2=C(C=C(C)C=C2O)C(C3=CC(OC)=CC(O)=C13)=O

• Molecular Formula:

  C16H12O5

• Molecular Weight:

  284.26

• References & Citations:

  [1]Lin R, et al. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17 (11) :1484-96.|[2]Pang MJ, et al. Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma. Acta Pharmacol Sin. 2016 Dec;37 (12) :1623-1640.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  [521-61-9]