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RNF40 Antibody / BRE1B

CAT: 0800-RQ7838Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ7838Size:100 µg
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Description
E3 ubiquitin-protein ligase BRE1B is an enzyme that in humans is encoded by the RNF40 gene. The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL, Immunofluorescence: 5 µg/mL, , Direct ELISA: 0.1-0.5 µg/mL
UniProt
O75150
Host
Rabbit
Reactivity
Human
Immunogen
E. coli-derived recombinant human protein (amino acids A99-D537) was used as the immunogen for the RNF40 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IF, Direct ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the RNF40 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This RNF40 antibody is available for research use only.
Storage Conditions
After reconstitution, the RNF40 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the RNF40 antibody should be determined by the researcher.
Location
Nuclear
Image Legend
IHC staining of FFPE human testicular seminoma tissue with RNF40 antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.

UniProtKB · O75150

E3 ubiquitin-protein ligase BRE1B

BRE1B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O75150
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
RNF40
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
BRE1-B
EC number
2.3.2.27
Processing
—
Secondary accessions
A0A024QZG0, Q6AHZ6, Q6N005, Q7L3T6, Q8N615, Q96T18, Q9BSV9, Q9HC82
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Molecular function

Chromatin regulatorTransferase

Domain

Coiled coilZinc-finger

Biological process

Host-virus interactionUbl conjugation pathway

Ligand

Metal-bindingZinc

Cellular component

Nucleus

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