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RNF20 Antibody / BRE1A

CAT: 0800-RQ7632Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ7632Size:100 µg
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Description
E3 ubiquitin-protein ligase BRE1A is an enzyme that in humans is encoded by the RNF20 gene. The protein encoded by this gene shares similarity with BRE1 of S. cerevisiae. The protein encoded by this human gene is an E3 ubiquitin ligase that regulates chromosome structure by monoubiquitinating histone H2B. This protein acts as a putative tumor suppressor and positively regulates the p53 tumor suppressor as well as numerous histone H2A and H2B genes. In contrast, this protein also suppresses the expression of several protooncogenes and growth-related genes, including many genes that are induced by epidermal growth factor. This gene selectively suppresses the expression of some genes by interfering with chromatin recruitment of transcription elongation factor SII (TFIIS) .
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL
UniProt
Q5VTR2
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
E. coli-derived recombinant human protein (amino acids E123-S389) was used as the immunogen for the RNF20 antibody.
Clonality
Monoclonal
Isotype
IgG2b
Clone
3C6E2
Applications
WB
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the RNF20 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This RNF20 antibody is available for research use only.
Storage Conditions
After reconstitution, the RNF20 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the RNF20 antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) human HeLa, 2) human MOLT4, 3) human 293T, 4) human A431, 5) rat brain and 6) mouse brain tissue lysate with RNF20 antibody. Predicted molecular weight ~114 kDa.

UniProtKB · Q5VTR2

E3 ubiquitin-protein ligase BRE1A

BRE1A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q5VTR2
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
RNF20
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
BRE1-A, hBRE1
EC number
2.3.2.27
Processing
—
Secondary accessions
A7MCT5, Q2TB34, Q69YL5, Q6P527, Q8N3J4, Q96JD3, Q9H9Y7, Q9HA51, Q9NUR4, Q9NWQ3, Q9NX83
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Molecular function

Chromatin regulatorTransferase

Domain

Coiled coilZinc-finger

Biological process

Host-virus interactionUbl conjugation pathway

Ligand

Metal-bindingZinc

Cellular component

Nucleus

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Alternative Products

CatalogName
abx402134-01E3 ubiquitin-protein ligase BRE1A (RNF20) Antibody
513692RNF20 (BRE1A) discontinued
041131RNF20, NT (RNF20, BRE1A, E3 ubiquitin-protein ligase BRE1A, RING finger protein 20)
MBS6342789-01RNF20, NT (RNF20, BRE1A, E3 ubiquitin-protein ligase BRE1A, RING finger protein 20) (FITC)
MBS6342796-01RNF20, NT (RNF20, BRE1A, E3 ubiquitin-protein ligase BRE1A, RING finger protein 20) (PE)
MBS6342788-01RNF20, NT (RNF20, BRE1A, E3 ubiquitin-protein ligase BRE1A, RING finger protein 20) (Biotin)
MBS6342787-01RNF20, NT (RNF20, BRE1A, E3 ubiquitin-protein ligase BRE1A, RING finger protein 20) (APC)
MBS6342786-01RNF20, NT (RNF20, BRE1A, E3 ubiquitin-protein ligase BRE1A, RING finger protein 20) (AP)
041131-PERNF20, NT (RNF20, BRE1A, E3 ubiquitin-protein ligase BRE1A, RING finger protein 20) (PE) discontinued
041131-APRNF20, NT (RNF20, BRE1A, E3 ubiquitin-protein ligase BRE1A, RING finger protein 20) (AP) discontinued

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