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PIG3 Antibody / TP53I3

CAT: 0800-RQ7669Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ7669Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Putative quinone oxidoreductase is an enzyme that in humans is encoded by the TP53I3 gene. The protein encoded by this gene is similar to oxidoreductases, which are enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL, Direct ELISA: 0.1-0.5 µg/mL
UniProt
Q53FA7
Host
Rabbit
Reactivity
Human
Immunogen
E. coli-derived recombinant human protein (amino acids M1-Q332) was used as the immunogen for the PIG3 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, Direct ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the PIG3 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This PIG3 antibody is available for research use only.
Storage Conditions
After reconstitution, the PIG3 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the PIG3 antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
IHC staining of FFPE human colon adenocarcinoma tissue with PIG3 antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.

UniProtKB · Q53FA7

Quinone oxidoreductase PIG3

QORX_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q53FA7
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TP53I3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.6.5.5
Processing
—
Secondary accessions
D6W533, O14679, O14685, Q38G78, Q6JLE7, Q9BWB8
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

Acetylation

Coding sequence diversity

Alternative splicing

Ligand

NADP

Molecular function

Oxidoreductase

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