MPP (hydrochloride)

CAT: 0804-HY-103454B-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-103454B-01Size:5 mg
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Description
MPP hydrochloride is a potent and selective ER (estrogen receptor) modulator. MPP hydrochloride induces significant apoptosis in the endometrial cancer and oLE cell lines. MPP hydrochloride reverses the the positive effects of beta-estradiol. MPP hydrochloride has mixed agonist/antagonist action on murine uterine ERalpha in vivo[1].
CAS Number
[2863676-89-3]
UNSPSC
12352005
Target
Apoptosis; Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Apoptosis; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/mpp-hydrochloride.html
Concentration
10mM
Purity
99.28
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
OC1=CC=C(C2=NN(C3=CC=C(O)C=C3)C(C4=CC=C(OCCN5CCCCC5)C=C4)=C2C)C=C1.[H]Cl
Molecular Formula
C29H32ClN3O3
Molecular Weight
506.04
References & Citations
[1]Davis AM, et al. The effects of the selective estrogen receptor modulators, methyl-piperidino-pyrazole (MPP), and raloxifene in normal and cancerous endometrial cell lines and in the murine uterus. Mol Reprod Dev. 2006 Aug;73 (8) :1034-44.|[2]Karaboğa Arslan AK, et al. α-Chaconine and α-Solanine Inhibit RL95-2 Endometrium Cancer Cell Proliferation by Reducing Expression of Akt (Ser473) and ERα (Ser167) . Nutrients. 2018 May 25;10 (6) . pii: E672.|[3]Labouesse MA, et al. Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice. Psychopharmacology (Berl) . 2015 Aug;232 (16) :2981-94.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERα; ERβ
Citation 01
Biochem Pharmacol. 2025 Dec;242 (Pt 4) :117432.|Biol Reprod. 2025 Jun 15;112 (6) :1114-1122.|Metab Brain Dis. 2022 Oct;37 (7) :2349-2362.|Biochem Pharmacol. 2024 May 9:225:116256.|Food Chem Toxicol. 2023 Jun:176:113792.|J Pharm Anal. 2025 Jul;15 (7) :101182.|Biomolecules. 2023 Jul 10;13 (7) :1097.|Drug Resist Updat. 2023 Nov:71:101014.|Ecotoxicol Environ Saf. 2023 Jul 1:259:115060.|Eur J Inflamm. October 11, 2021.|Mol Nutr Food Res. 2021 Sep;65 (17) :e2100070.|Phytomedicine. 2022 May:99:154022.|Phytomedicine. 2024 Jan:123:155218.

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