MPP (hydrochloride)

• UNSPSC Description:

  MPP hydrochloride is a potent and selective ER (estrogen receptor) modulator. MPP hydrochloride induces significant apoptosis in the endometrial cancer and oLE cell lines. MPP hydrochloride reverses the the positive effects of beta-estradiol. MPP hydrochloride has mixed agonist/antagonist action on murine uterine ERalpha in vivo[1].

• Target Antigen:

  Apoptosis; Estrogen Receptor/ERR

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/mpp-hydrochloride.html

• Purity:

  99.28

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  OC1=CC=C(C2=NN(C3=CC=C(O)C=C3)C(C4=CC=C(OCCN5CCCCC5)C=C4)=C2C)C=C1.[H]Cl

• Molecular Weight:

  506.04

• References & Citations:

  [1]Davis AM, et al. The effects of the selective estrogen receptor modulators, methyl-piperidino-pyrazole (MPP), and raloxifene in normal and cancerous endometrial cell lines and in the murine uterus. Mol Reprod Dev. 2006 Aug;73(8):1034-44.|[2]Karaboğa Arslan AK, et al. α-Chaconine and α-Solanine Inhibit RL95-2 Endometrium Cancer Cell Proliferation by Reducing Expression of Akt (Ser473) and ERα (Ser167). Nutrients. 2018 May 25;10(6). pii: E672.|[3]Labouesse MA, et al. Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice. Psychopharmacology (Berl). 2015 Aug;232(16):2981-94.Metab Brain Dis. 2022 Jul 2.|Biochem Pharmacol. 2024 May 9:225:116256.|Food Chem Toxicol. 2023 Apr 18;113792.|Biomolecules. 2023 Jul 10, 13(7), 1097.|Drug Resist Updat. 2023 Oct 26:71:101014.|Ecotoxicol Environ Saf. 2023 May 23;259:115060.|Eur J Inflamm. October 11, 2021.|Mol Nutr Food Res. 2021 Jul 5;e2100070.|Phytomedicine. 2023 Nov 14:123:155218.|Phytomedicine. 27 February 2022, 154022.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  2863676-89-3