Products for Research Use Only
RegisterLogin

P-MPPI (hydrochloride)

CAT: 0804-HY-120738-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-120738-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
P-MPPI hydrochloride is a selective 5-HT1A receptor antagonist with high affinity for 5-HT1A receptors. p-MPPI hydrochloride can crosses the blood-brain barrier, and has clear antidepressant and anxiolytic-like effects[1][2].
CAS Number
220643-77-6
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/p-mppi-hydrochloride.html
Purity
99.81
Solubility
DMSO : 17.86 mg/mL (ultrasonic) |H2O : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=C(C=C1)I)N(C2=NC=CC=C2)CCN3CCN(CC3)C4=CC=CC=C4OC.[H]Cl
Molecular Formula
C25H28ClIN4O2
Molecular Weight
578.87
References & Citations
[1]Sørensen E, et al. The selective 5-HT (1A) receptor antagonist p-MPPI antagonizes sleep--waking and behavioural effects of 8-OH-DPAT in rats. Behav Brain Res. 2001 Jun;121 (1-2) :181-7.|[2]Cao BJ, et al. Anxiolytic-like profile of p-MPPI, a novel 5HT1A receptor antagonist, in the murine elevated plus-maze. Psychopharmacology (Berl) . 1997 Feb;129 (4) :365-71.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor; mLAG-3

Chemical Information

p-MPPI monohydrochloride
CAS Number220643-77-6
PubChem CID11957651
IUPAC Name4-iodo-N-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-N-pyridin-2-ylbenzamide;hydrochloride
Molecular FormulaC25H28ClIN4O2
Molecular Weight578.9
Topological Polar Surface Area48.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Heavy Atom Count33
Formal Charge0
Complexity578
SMILES
COC1=CC=CC=C1N2CCN(CC2)CCN(C3=CC=CC=N3)C(=O)C4=CC=C(C=C4)I.Cl
InChI
InChI=1S/C25H27IN4O2.ClH/c1-32-23-7-3-2-6-22(23)29-17-14-28(15-18-29)16-19-30(24-8-4-5-13-27-24)25(31)20-9-11-21(26)12-10-20;/h2-13H,14-19H2,1H3;1H
InChIKey
PBPBIDMIRMWUCI-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of p-MPPI monohydrochloride
CAS: 220643-77-6
CID: 11957651
Formula: C25H28ClIN4O2
MW: 578.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight578.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass578.09455
Monoisotopic Mass578.09455
Topological Polar Surface Area48.9 Ų
Heavy Atom Count33
Formal Charge0
Complexity578
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-172059-013C-P (hydrochloride)
HY-W014134P-APMSF (hydrochloride)
HY-112658-01P-Iodoclonidine (hydrochloride)
HY-23460A-01P-Ethynylphenylalanine (hydrochloride)
HY-W743525-01(±) -p-Fluoro pseudoephedrine (hydrochloride)
HY-1725473-p-FBT (hydrochloride)
HY-W016823S-01P-Tyramine-d4 (hydrochloride)
HY-137388A-01P-F-HHSiD (hydrochloride)
HY-158071P-SCN-Bn-HEHA (hydrochloride)
HY-153219-01P-CAB agent 2 (hydrochloride)

Alternative Products

CatalogName
T16421-01P-MPPI hydrochloride
XHA77177-01P-Hydroxycocaine hydrochloride
90780-01P-Rosaniline Hydrochloride
P3402-050p-APMSF. Hydrochloride
T37019-01P-APMSF (hydrochloride)
461865-01P-Iodoclonidine Hydrochloride
MBS3614679-01p-Ethynylphenylalanine hydrochloride
TRC-C377740-25MGp-Chlorophenylguanidine Hydrochloride
TRC-H791720-10MGp-Hydroxymephentermine Hydrochloride
sc-257961P-Tolylhydrazine hydrochloride

Popular Products