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MPP (dihydrochloride)

CAT: 0804-HY-103454-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-103454-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MPP dihydrochloride is a potent and selective ER (estrogen receptor) modulator. MPP dihydrochloride induces significant apoptosis in the endometrial cancer and oLE cell lines. MPP dihydrochloride reverses the positive effects of beta-estradiol. MPP dihydrochloride has mixed agonist/antagonist action on murine uterine ERalpha in vivo[1][2][3].
CAS Number
911295-24-4
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Apoptosis; Estrogen Receptor/ERR
Type
Reference compound
Related Pathways
Apoptosis; Vitamin D Related/Nuclear Receptor
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/mpp-dihydrochloride.html
Purity
99.54
Solubility
DMSO : 30 mg/mL (ultrasonic; warming)
Smiles
OC1=CC=C(C2=NN(C3=CC=C(O)C=C3)C(C4=CC=C(OCCN5CCCCC5)C=C4)=C2C)C=C1.[H]Cl.[H]Cl
Molecular Formula
C29H33Cl2N3O3
Molecular Weight
542.50
Precautions
H315, H319, H335
References & Citations
[1]Karaboğa Arslan AK, et al. α-Chaconine and α-Solanine Inhibit RL95-2 Endometrium Cancer Cell Proliferation by Reducing Expression of Akt (Ser473) and ERα (Ser167) . Nutrients. 2018 May 25;10 (6) . pii: E672.|[2]Labouesse MA, et al. Effects of selective estrogen receptor alpha and beta modulators on prepulse inhibition in male mice. Psychopharmacology (Berl) . 2015 Aug;232 (16) :2981-94.|[3]Davis AM, et al. The effects of the selective estrogen receptor modulators, methyl-piperidino-pyrazole (MPP), and raloxifene in normal and cancerous endometrial cell lines and in the murine uterus. Mol Reprod Dev. 2006 Aug;73 (8) :1034-44.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERα; ERβ
Citation 01
Biomolecules. 2023 Jul 10;13 (7) :1097.|Drug Resist Updat. 2023 Nov:71:101014.|Ecotoxicol Environ Saf. 2023 Jul 1:259:115060.|Eur J Inflamm. October 11, 2021.|Mol Nutr Food Res. 2021 Sep;65 (17) :e2100070.|Phytomedicine. 2022 May:99:154022.|Phytomedicine. 2024 Jan:123:155218.|Biochem Pharmacol. 2024 May 9:225:116256.|Food Chem Toxicol. 2023 Jun:176:113792.|J Pharm Anal. 2025 Jul;15 (7) :101182.|Biochem Pharmacol. 2025 Dec;242 (Pt 4) :117432.|Biol Reprod. 2025 Jun 15;112 (6) :1114-1122.|Metab Brain Dis. 2022 Oct;37 (7) :2349-2362.

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