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RB3 Polyclonal Antibody

CAT: 0965-JOT-AP07697-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP07697-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
RB3 (Stathmin-4), encoded by STMN4 gene, is a neuron-specific homologue of the SCG10/stathmin family proteins, possessing a unique N-terminal membrane-associated domain and the stathmin-like domain at the C terminus, which promotes microtubule (MT) catastrophe and/or tubulin sequestering. Stathmin is a ubiquitous cytosolic phosphoprotein, preferentially expressed in the nervous system, and described as a relay integrating diverse intracellular signaling pathways. RB3 is consistently up-regulated in differentiated neuroblastoma cells, and stable expression of transfected RB3 could induce differentiation, suggesting a role of RB3 during neuroblastoma differentiation. Moreover, increased RB3 is a unique response protein in the stathmin-related proteins following optical nerve axotomy and RB3 may be a critical target for neurodegenerative diseases.
CAS Number
9007-83-4
Synonyms
STMN4; Stathmin-4; Stathmin-like protein B3; RB3
Host
Rabbit
Reactivity
Human;Mouse;Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human STMN4. AA range:140-189
Clonality
Polyclonal
Applications
WB, IHC-p, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
22071
Antibody Type
Primary antibody
Isotype
IgG