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Raf-1 Polyclonal Antibody

CAT: 0965-JOT-AP13534-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP13534-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
CAS Number
9007-83-4
Synonyms
RAF proto-oncogene serine/threonine-protein kinase; RAF1; RAF; RAF proto-oncogene serine/threonine-protein kinase; Proto-oncogene c-RAF; cRaf; Raf-1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human C-RAF. AA range:591-640
Clonality
Polyclonal
Applications
WB, IHC-p, IF, ICC, ELISA
Stability
-20°C for 1 year
Concentration
1 mg/ml
Molecular Weight
73052
Antibody Type
Primary antibody
Isotype
IgG

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