Products for Research Use Only
RegisterLogin

53BP1 Polyclonal Antibody

CAT: 0965-JOT-AP00040-01Size: 20 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0965-JOT-AP00040-01Size:20 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
The p53 binding proteins 53BP1 and 53BP2 (Bbp) bind to the central DNA-binding domain of wild type p53, but do not bind mutant p53. The central DNA-binding domain of p53 is required for site-specific DNA binding and is frequently mutated in malignant tumors. Binding of 53BP1 to the L3 loop of p53 and of 53BP2 to the L2 loop of p53 confirms that the loop is dependent on p53 conformation. Site-specific binding also suggests that 53BP1 and 53BP2 are involved in p53-mediated tumor suppression. 53BP1 was isolated from H258 cells and is expressed in Jurkat cells in both the cytoplasm and the nucleus. The N-terminus of 53BP2 is localized to the cytoplasm, while the C-terminus might be localized in the nucleus. 53BP1 promotes cell proliferation by binding to p202, whereas 53BP2 induces cell death by binding to Bcl2 and NFkB p65.
CAS Number
9007-83-4
Synonyms
TP53BP1; Tumor suppressor p53-binding protein 1; 53BP1; p53-binding protein 1; p53BP1
Host
Rabbit
Reactivity
Human
Immunogen
The antiserum was produced against synthesized peptide derived from human TP53BP1. AA range:1744-1793
Clonality
Polyclonal
Applications
IHC-p, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
213574
Antibody Type
Primary antibody
Isotype
IgG

Related Products

CatalogName
JOT-PHS00710-01Phospho-53BP1 (S6) Polyclonal Antibody
JOT-PHS01140-01Phospho-53BP1 (S25) Polyclonal Antibody
JOT-AP00164-0153BP1(Phospho-Ser1778) Rabbit Polyclonal Antibody
JOT-AP00165-0153BP1(Phospho-Thr543) Rabbit Polyclonal Antibody
JOT-AP00163-0153BP1(Phospho-Ser1618) Rabbit Polyclonal Antibody
JOT-AP01329-01CD10 Polyclonal Antibody
JOT-AP01765-01Chk1 Polyclonal Antibody
JOT-AP01456-01CD300d Polyclonal Antibody
JOT-AP02080-01COL2A1 Polyclonal Antibody
JOT-AP01580-01Cdc25B Polyclonal Antibody

Alternative Products

CatalogName
MBS8521006-0153BP1 Polyclonal Antibody

Popular Products