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Anti-inflammatory agent 79

CAT: 0804-HY-163512Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163512Size:1 Each
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Description
Anti-inflammatory agent 79 (compound 17q) is an isoquinolinone derivative-based HIF-1 inhibitor (IC50: 0.55 μM), which can effectively block HIF-1 signals and increase HIF- Degradation of 1α. Anti-inflammatory agent 79 inhibits synovial invasion and migration and inhibits angiogenesis. Anti-inflammatory agent 79 also effectively reduced foot swelling and arthritis in a mouse inflammation model, and down-regulated the levels of inflammatory factors and blood vessel proliferation in the body[1].
CAS Number
9007-83-4
UNSPSC
12352005
Target
HIF/HIF Prolyl-Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/anti-inflammatory-agent-79.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(C2=COC=C2)C=C1C=C3)N3CCC4=CC=CC=C4
Molecular Formula
C21H17NO2
Molecular Weight
315.37
References & Citations
[1]Cai L, et al. Discovery of novel diaryl substituted isoquinolin-1 (2H) -one derivatives as hypoxia-inducible factor-1 signaling inhibitors for the treatment of rheumatoid arthritis. Eur J Med Chem. 2024 Apr 16;271:116417.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HIF-1α

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