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L 366509

CAT: 0804-HY-15007Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-15007Size:1 Each
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Description
L 366509 is a spiroindenylpiperidine camphorsulfonamide oxytocin (OT) antagonist. Modifications led to a new series of o-tolylpiperazine (TP) camphorsulfonamides, exhibiting high affinity for OT receptors and selectivity over arginine vasopressin receptors. Notably, compound 7 (L-368,899) showed excellent OT receptor affinity, potency in inhibiting OT-stimulated uterine contractions, good aqueous solubility, and oral bioavailability in multiple species. Compound 7 has entered clinical testing as an oral and intravenous tocolytic agent. Molecular modeling suggests the TP camphorsulfonamide structure mimics the D-AA2-Ile3 dipeptide, crucial in potent OT antagonists[1].
CAS Number
138382-23-7
UNSPSC
12352005
Target
Oxytocin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/l-366509.html
Smiles
O=S(N(CC1)CCC21C3=CC=CC=C3C=C2)(C[C@]4(C5(C)C)CC[C@@H]5C[C@@]4(CC(O)=O)O)=O
Molecular Formula
C25H33NO5S
Molecular Weight
459.60
References & Citations
[1]1- (((7,7-Dimet hyl-2 (S) - (2 (S) -amino-4- (met hylsulfonyl) butyramido) bicyclo[2.2.1]- heptan-l (S) -yl) methyl) sulfonyl) -4- (2-methylphenyl) piperazine (L-368,899) : An Orally Bioavailable, Non-Peptide Oxytocin Antagonist with Potential Utility for Managing Preterm Labor
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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