γ-L-Glutamyl-L-alanine

• UNSPSC Description:

  γ-L-Glutamyl-L-alanine, composed of gamma-glutamate and alanine, is a proteolytic breakdown product of larger proteins. γ-L-Glutamyl-L-alanine is a natural substrate of the γ-Glutamylcyclotransferase. γ-L-Glutamyl-L-alanine is a positive modulator of calcium-sensing receptor (CaR) function[1][2][3][4].

• Target Antigen:

  CaSR; Endogenous Metabolite

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Metabolic Enzyme/Protease

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/_gamma_-L-Glutamyl-L-alanine.html

• Purity:

  98.0

• Solubility:

  DMSO : < 1 mg/mL|H2O : ≥ 50 mg/mL

• Smiles:

  OC([C@@H](N)CCC(N[C@@H](C)C(O)=O)=O)=O

• Molecular Weight:

  218.21

• References & Citations:

  [1]Ovchinnikova OG, et al. Structure of a polysaccharide from Providencia rustigianii O11 containing a novel amide of 2-acetamido-2-deoxygalacturonic acid with L-glutamyl-L-alanine. Carbohydr Res. 2012 Feb 15;349:95-102.|[2]York MJ, et al. gamma-Glutamylcyclotransferase: inhibition by D-beta-aminoglutaryl-L-alanine and analysis of the solvent kinetic isotope effect. Eur J Biochem. 1989 Sep 1;184(1):97-101. |[3]Broadhead GK, et al. Allosteric modulation of the calcium-sensing receptor by gamma-glutamyl peptides: inhibition of PTH secretion, suppression of intracellular cAMP levels, and a common mechanism of action with L-amino acids. J Biol Chem. 2011 Mar 18;286(11):8786-97. |[4]Tatsuo Yamamoto, et al. Further Characterization of Glutaminase Isozymes from Pseudomonas aeruginosa.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  5875-41-2