Human DNMT3B/DNMT3L Complex (recombinant)

• Description:

  Human DNMT3B/DNMT3L Complex (recombinant)_x000D_ Catalog number: B2016789_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 10 µg_x000D_ Molecular Weight or Concentration: 59 kDa (DNMT3B) and 27 kDa (DNMT3L)_x000D_ Supplied as: Solution_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: -80°C_x000D_ Keywords: DNA (Cytosine-5)-Methyltransferase 3B, DNA (Cytosine-5)-Methyltransferase 3-Like, DNA Methyltransferase HsaIIIB, DNA MTase HsaIIIB, M.HsaIIIB_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Gao L, Guo Y, Biswal M, Lu J, Yin J, Fang J, Chen X, Shao Z, Huang M, Wang Y, Wang GG, Song J. Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations Nat Commun. 2022 Jul 22;13(1):4249._x000D_ 2: Cho CC, Lin CJ, Huang HH, Yang WZ, Fei CY, Lin HY, Lee MS, Yuan HS. Mechanistic Insights into Harmine-Mediated Inhibition of Human DNA Methyltransferases and Prostate Cancer Cell Growth ACS Chem Biol. 2023 Jun 16;18(6):1335-1350._x000D_ 3: Jiang Y, Schneck JL, Grimes M, Taylor AN, Hou W, Thrall SH, Sweitzer SM. Methyltransferases prefer monomer over core-trimmed nucleosomes as in vitro substrates Anal Biochem. 2011 Aug 1;415(1):84-6._x000D_ 4: Zhu X, Xue C, Kang X, Jia X, Wang L, Younis MH, Liu D, Huo N, Han Y, Chen Z, Fu J, Zhou C, Yao X, Du Y, Cai W, Kang L, Lyu Z. DNMT3B-mediated FAM111B methylation promotes papillary thyroid tumor glycolysis, growth and metastasis Int J Biol Sci. 2022 Jul 4;18(11):4372-4387._x000D_ 5: Zhang H, Ying H, Wang X. Methyltransferase DNMT3B in leukemia Leuk Lymphoma. 2020 Feb;61(2):263-273._x000D_ 6: Li G, Luo R, Zhang W, He S, Wang B, Liang H, Song Y, Ke W, Shi Y, Feng X, Zhao K, Wu X, Zhang Y, Wang K, Yang C. m6A hypomethylation of DNMT3B regulated by ALKBH5 promotes intervertebral disc degeneration via E4F1 deficiency Clin Transl Med. 2022 Mar;12(3):e765._x000D_ 7: Gagliardi M, Strazzullo M, Matarazzo MR. DNMT3B Functions: Novel Insights From Human Disease Front Cell Dev Biol. 2018 Oct 22;6:140._x000D_ 8: Man X, Li Q, Wang B, Zhang H, Zhang S, Li Z. DNMT3A and DNMT3B in Breast Tumorigenesis and Potential Therapy Front Cell Dev Biol. 2022 May 10;10:916725._x000D_ 9: Okano M, Bell DW, Haber DA, Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development Cell. 1999 Oct 29;99(3):247-57._x000D_ 10: Andrews S, Krueger C, Mellado-Lopez M, Hemberger M, Dean W, Perez-Garcia V, Hanna CW. Mechanisms and function of de novo DNA methylation in placental development reveals an essential role for DNMT3B Nat Commun. 2023 Jan 23;14(1):371. _x000D_ _x000D_ Products Related to Human DNMT3B/DNMT3L Complex (recombinant) can be found at Proteins

• Short Description:

  Catalog Number: B2016789 (10 µg)_x000D_ Human DNMT3B/DNMT3L Complex (recombinant) is a high quality protein complex that consists of two proteins: DNMT3B and DNMT3L. DNMT3B is a DNA methyltransferase enzyme that is involved in adding methyl groups to DNA, which can regulate gene expression. DNMT3L is a regulatory protein that interacts with DNMT3B to enhance its activity._x000D_ _x000D_ This recombinant complex is produced in a laboratory setting using genetic engineering techniques to create a purified form of the protein complex for research purposes. Scientists use this complex to study DNA methylation processes and their role in gene regulation and other biological functions.. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3