Recombinant METTL1 / WDR4 Complex

• Description:

  Recombinant METTL1 / WDR4 Complex_x000D_ Catalog number: B2017655_x000D_ Lot number: Batch Dependent_x000D_ Expiration Date: Batch dependent_x000D_ Amount: 10 µg_x000D_ Molecular Weight or Concentration: 45.5 kDa_x000D_ Supplied as: SOLUTION_x000D_ Applications: a molecular tool for various biochemical applications_x000D_ Storage: -80°C_x000D_ Keywords: N/A_x000D_ Grade: Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity >18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ References:_x000D_ 1: Cheng W, Gao A, Lin H, Zhang W. Novel roles of METTL1/WDR4 in tumor via m(7)G methylation Mol Ther Oncolytics. 2022 Jun 7;26:27-34._x000D_ 2: Li J, Wang L, Hahn Q, Nowak RP, Viennet T, Orellana EA, Roy Burman SS, Yue H, Hunkeler M, Fontana P, Wu H, Arthanari H, Fischer ES, Gregory RI. Structural basis of regulated m(7)G tRNA modification by METTL1-WDR4 Nature. 2023 Jan;613(7943):391-397._x000D_ 3: Ruiz-Arroyo VM, Raj R, Babu K, Onolbaatar O, Roberts PH, Nam Y. Structures and mechanisms of tRNA methylation by METTL1-WDR4 Nature. 2023 Jan;613(7943):383-390._x000D_ 4: Huang M, Long J, Yao Z, Zhao Y, Zhao Y, Liao J, Lei K, Xiao H, Dai Z, Peng S, Lin S, Xu L, Kuang M. METTL1-Mediated m7G tRNA Modification Promotes Lenvatinib Resistance in Hepatocellular Carcinoma Cancer Res. 2023 Jan 4;83(1):89-102._x000D_ 5: Lin S, Liu Q, Lelyveld VS, Choe J, Szostak JW, Gregory RI. Mettl1/Wdr4-Mediated m(7)G tRNA Methylome Is Required for Normal mRNA Translation and Embryonic Stem Cell Self-Renewal and Differentiation Mol Cell. 2018 Jul 19;71(2):244-255.e5._x000D_ 6: Chen J, Li K, Chen J, Wang X, Ling R, Cheng M, Chen Z, Chen F, He Q, Li S, Zhang C, Jiang Y, Chen Q, Wang A, Chen D. Aberrant translation regulated by METTL1/WDR4-mediated tRNA N7-methylguanosine modification drives head and neck squamous cell carcinoma progression Cancer Commun (Lond). 2022 Mar;42(3):223-244._x000D_ 7: Han H, Yang C, Ma J, Zhang S, Zheng S, Ling R, Sun K, Guo S, Huang B, Liang Y, Wang L, Chen S, Wang Z, Wei W, Huang Y, Peng H, Jiang YZ, Choe J, Lin S. N(7)-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis Nat Commun. 2022 Mar 18;13(1):1478._x000D_ 8: Ma J, Han H, Huang Y, Yang C, Zheng S, Cai T, Bi J, Huang X, Liu R, Huang L, Luo Y, Li W, Lin S. METTL1/WDR4-mediated m(7)G tRNA modifications and m(7)G codon usage promote mRNA translation and lung cancer progression Mol Ther. 2021 Dec 1;29(12):3422-3435._x000D_ 9: Singh S, Yeat NY, Wang YT, Lin SY, Kuo IY, Wu KP, Wang WJ, Wang WC, Su WC, Wang YC, Chen RH. PTPN23 ubiquitination by WDR4 suppresses EGFR and c-MET degradation to define a lung cancer therapeutic target Cell Death Dis. 2023 Oct 11;14(10):671._x000D_ 10: Chen Z, Zhu W, Zhu S, Sun K, Liao J, Liu H, Dai Z, Han H, Ren X, Yang Q, Zheng S, Peng B, Peng S, Kuang M, Lin S. METTL1 promotes hepatocarcinogenesis via m(7) G tRNA modification-dependent translation control Clin Transl Med. 2021 Dec;11(12):e661. _x000D_ _x000D_ Products Related to Recombinant METTL1 / WDR4 Complex can be found at Proteins

• Short Description:

  Catalog Number: B2017655 (10 µg)_x000D_ The complex consists of two subunits, METTL1 and WDR4. METTL1 is a methyltransferase enzyme that methylates tRNA at position 58, while WDR4 is a WD repeat-containing protein crucial for METTL1's stability and activity. This complex regulates protein synthesis by modifying tRNA molecules. This product has been used as a molecular tool for various biochemical applications. It has also been used in a wide array of other chemical and immunological applications. Custom bulk amounts of this product are available upon request._x000D_ _x000D_

• Weight:

  0.15

• Length:

  2

• Width:

  0.5

• Height :

  0.5

• CAS Number:

  9000-83-3