Products for Research Use Only
RegisterLogin

RecombinantNoggin, Human (CHO-expressed)

CAT: 0384-BK0277-01Size: 10 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0384-BK0277-01Size:10 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Noggin, also known as NOG, is a homodimeric glycoprotein that bindsto and modulates the activity of TGF-beta family ligands. It is expressed in condensing cartilage and immature chondrocytes. Noggin antagonizes bone morphogenetic protein (BMP) activities by blocking epitopes on BMPs needed for binding to their receptors. Noggin has been shown to be involved in many developmental processes, such as neural tube formation and joint formation. During development, Noggin diffuses through extracellular matrices and forms morphogenic gradients, regulating cellular responses dependent on the local concentration of the signaling molecule.
CAS Number
9000-83-3
Endotoxin
<0.2 EU/μg, determined by LAL method.
Purity
> 95% as analyzed by SDS-PAGE.
Bioactivity
ED50<2.5 ng/ml, measured in a bioassay using ATDC5 cells in the presence of 10ng/ml human BMP-4.
Reconstitution
Reconstituted in ddH2O or PBS at 100 μg/ml.
Molecular Weight
29-31kDa, observed by reducing SDS-PAGE.
Storage Conditions
Lyophilized recombinant human Noggin remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, human Nogginshould be stable up to 1 week at 4°C or up to 2 months at -20°C.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
Lyophilized after extensive dialysis against PBS.
Host or Source
CHO
Recommended Usage
This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. For research use only.
AA Sequence
QHYLHIRPAPSDNLPLVDLIEHPDPIFDPKEKDLNETLLRSLLGGHYDPGFMATSPPEDR PGGGGGAAGGAEDLAELDQLLRQRPSGAMPSEIKGLEFSEGLAQGKKQRLSKKLRRKLQM WLWSQTFCPVLYAWNDLGSRFWPRYVKVGSCFSKRSCSVPEGMVCKPSKSVHLTVLRWRC QRRGGQRCGWIPIQYPIISECKCSC

Related Products

CatalogName
BK0278-01RecombinantNoggin, Mouse (CHO-expressed)
BK0210-01RecombinantGH, Human (CHO-expressed)
BK0197-01RecombinantEpigen, Human (CHO-expressed)
BK0223-01RecombinantIFN-γ, Human (CHO-expressed)
BK0182-01RecombinantAdiponectin, Human (CHO-expressed)
BK0243-01RecombinantIL-3, Human (CHO-expressed)
BK0267-01RecombinantM-CSF, Human (CHO-expressed)
BK0228-01RecombinantIL-11, Human (CHO-expressed)
BK0217-01RecombinantGRO-γ/CXCL3, Human (CHO-expressed)
BK0232-01RecombinantIL-13, Human (CHO-expressed)

Alternative Products

CatalogName
BK0277RecombinantNoggin,Human(CHO-expressed)
GTR18990263-01RecombinantNoggin, Human (CHO-expressed)
BK0278RecombinantNoggin,Mouse(CHO-expressed)
GTR18990262-01RecombinantNoggin, Mouse (CHO-expressed)
Z03005-50GH, Human (CHO-expressed)
Z02986-10IFN-γ, Human (CHO-expressed)
BK0223RecombinantIFN-γ,Human(CHO-expressed)
GTR18990319-01RecombinantIFN-γ, Human (CHO-expressed)
Z03212-50Noggin, Human (CHO-expressed)
BK0182RecombinantAdiponectin,Human(CHO-expressed)

Popular Products