RecombinantNT-4, Human

CAT: 0384-BK0144-01Size: 10 µgDry Ice: NoHazardous: No
CAT#:0384-BK0144-01Size:10 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Neurotrophin-4 (NT-4), also known as NT-5, is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-3. Human NT-4 shares 48 - 52% aa sequence identity with human β-NGF, BDNF, and NT-3.Neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds. NT-4 is expressed highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. NT-4 binds and induces receptor dimerization and activation of TrkB. NT-4 can signal through TrkB receptors and promotes the survival of peripheral sensory sympathetic neurons.Recombinant human Neurotrophin-4 (rhNT-4) produced in E.coli is a noncovalently linked homodimer containing two non-glycosylated polypeptide chains of 131 amino acids. A fully biologically active molecule, rhNT-4 has a molecular mass of 28.1kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
CAS Number
9000-83-3
Endotoxin
< 0.3 EU/μg, determined by LAL method.
Purity
> 95% by SDS-PAGE and HPLC analyses.
Bioactivity
ED50 < 5.0 μg/ml, measured by a cell proliferation assay using C6 cells, corresponding to a specific activity of > 2.0x 10ˆ2 units/mg.
Reconstitution
Reconstituted in 50mM acetic acid or ddH2O at 50 μg/ml.
Molecular Weight
28.1 kDa, a noncovalently linked homodimer, of two 14.0 kDa polypeptide monomers.
Storage Conditions
Lyophilized recombinant human Neurotrophin-4 (rhNT-4) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhNT-4 should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
Lyophilized after extensive dialysis against 50mM acetic acid.
Host or Source
Escherichia coli.
Recommended Usage
This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. For research use only.
AA Sequence
MGVSETAPA SRRGELAVCD AVSGWVTDRR TAVDLRGREV EVLGEVPAAG GSPLRQYFFE TRCKADNAEE GGPGAGGGGC RGVDRRHWVS ECKAKQSYVR ALTADAQGRV GWRWIRIDTA CVCTLLSRTG RA

Related Products

CatalogName
BK0145-01RecombinantNT-4, Mouse
BK0245-01RecombinantIL-4, Human
PR1072-01Recombinant Human Interleukin-4 (rHuIL-4)
PR1102-01Recombinant Human Neurotrophin-4 (rHuNT-4)
PR1117-01Recombinant Human Syndecan-4 (rHuSDC-4)
BK0328-01RecombinantPF-4/CXCL4, Human
PR1098-01Recombinant Human MIP-4 (rHuMIP-4/CCL18)
PR1088-01Recombinant Human MCP-4 (rHuMCP-4/CCL13)
PR1122-01Recombinant Human Thymosin Beta 4 (rHuTβ4)
PR1010-01Recombinant Human beta-Defensin 4 (rHuBD-4)

Alternative Products

CatalogName
BK0144RecombinantNT-4,Human
SR106-0020Interleukin-4 (IL-4), Human
RC218-15NT-4, Neurotrophin-4, human
GWB-2A39E4Interleukin-4 (IL-4) Human
RC212-15IL-4, Interleukin-4, human
PT_41641-01Neurotrophin-4 Human Recombinant (NT 4 Human)
PT_41195-01Interleukin-4 Human Recombinant (IL 4 Human)
PT_40365-01Beta Defensin-4 Human Recombinant (BD 4 Human)
PT_39822-014-1BB Ligand Human Recombinant (4 1BBL Human)
CX03-500ugRecombinant Human Interleukin-4/IL-4 (Human Cells)

Popular Products