RecombinantDKK-1, Human

CAT: 0384-BK0023-01Size: 10 µgDry Ice: NoHazardous: No
CAT#:0384-BK0023-01Size:10 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Dickkopf related protein 1 (DKK1) is a chemokine that belongs to the DKK protein family, which alsoincludes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. It is one of the most up-regulated genes during androgen-potentiated balding, with DKK-1 messenger RNA up-regulated a few hours after DHT treatment of hair follicles at the dermal papilla in vitro. Neutralizing bodies against DKK-1 reverses DHT effects on outer root sheath keratinocytes. DKK-1 expression is attenuated by L-threonate, a metabolite of ascorbatein vitro. DKK1 promotes LRP6 internalization and degradation as it forms a ternary complex with the cell surface receptor Kremen. DKK1 not only functions as a head inducer during development, but also regulates joint remodeling and bone formation, which indicate sits role in the pathogenesis of rheumatoid arthritis and multiple myeloma.
CAS Number
9000-83-3
Endotoxin
< 0.2 EU/μg, determined by LAL method.
Purity
> 95% as analyzed by SDS-PAGE.
Bioactivity
ED50 < 6 µg/ml, measured in stimulation of alkaline phosphatase activity using CCl-226 cells. Up to 180% stimulation of alkaline phosphatase activity was observed at 10.0 ug/ml.
Reconstitution
Reconstituted in ddH2O or PBS at 100 μg/ml.
Molecular Weight
17-22 kDa, observed by reducing SDS-PAGE.
Storage Conditions
Lyophilized recombinant human DKK1 (rhDKK1) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhDKK1 should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Appearance
Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation
Lyophilized after extensive dialysis against PBS.
Host or Source
Escherichia coli.
Recommended Usage
This material is offered by USA Bioworld biotech for research, laboratory or further evaluation purposes. For research use only.
AA Sequence
TLNSVLNSNAIKNLPPPLGGAAGHPGSAVSAAPGILYPGGNKYQTIDNYQPYPCAEDEEC GTDEYCASPTRGGDAGVQICLACRKRRKRCMRHAMCCPGNYCKNGICVSSDQNHFRGEIE ETITESFGNDHSTLDGYSRRTTLSSKMYHTKGQEGSVCLRSSDCASGLCCARHFWSKICK PVLKEGQVCTKHRRKGSHGLEIFQRCYCGEGLSCRIQKDHHQASNSSRLHTCQRH

Related Products

CatalogName
BK0193-01RecombinantDKK-1, Mouse
BK0021-01RecombinantDHH, Human
BK0022-01RecombinantDHH, Mouse
BK0076-01RecombinantHRG1-β1, Human
BK0094-01RecombinantIL-1β, Human
BK0295-01RecombinantWISP-1, Human
BK0191-01RecombinantCT-1, Human
PR1077-01Recombinant Human Kallikrein-1 (rHuKLK-1)
PR1050-01Recombinant Human Interferon-λ1 (rHu IFN-λ1)
PR1054-01Recombinant Human Interleukin-1 alpha (rHuIL-1α)

Alternative Products

CatalogName
BK0023RecombinantDKK-1,Human
MBS659788-01Defensin 1 (human) (Human Neutrophil Peptide-1, HNP-1)
PT_40089-01Cardiotrophin-1 Human Recombinant (CT 1 Human)
PT_40477-01Elk-1 Human Recombinant (Elk-1 Human)
PT_42136-01Stanniocalcin-1 Human Recombinant (STC 1 Human)
PT_40012-01BP-1 Human Recombinant (BP-1 Human)
MBS2600581-01Human Netrin 1 (Ntn 1)
MBS5818489Endothelin-1 (1-31)(Human)
003-26Nesfatin-1 (1-82) (Human)
HY-P4159-01Endothelin-1 (1-31) (Human)

Popular Products