PJA2 polyclonal antibody

• Background:

  Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype.

• Structure Composition:

  1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative:

  KIAA0438; RNF131; E3 ubiquitin-protein ligase Praja-2; Praja2; RING finger protein 131

• Swiss Prot:

  O43164

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  KLH-conjugated synthetic peptide encompassing a sequence within the center region of human PJA2.

• Conjugation:

  Unconjugated

• Applications:

  WB

• Dilution:

  WB,1:500 - 1:1000

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodified

• Molecular Weight:

  ~ 78 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  PJA2 polyclonal antibody detects endogenous levels of PJA2 protein.

• Applications Notes:

  Western blot analysis of PJA2 expression in HeLa (A), HL60 (B) whole cell lysates.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4