ATF6 polyclonal antibody

CAT: 0384-BS6476-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS6476-01Size:50 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
This gene encodes a transcription factor that activates target genes for the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Although it is a transcription factor, this protein is unusual in that it is synthesized as a transmembrane protein that is embedded in the ER. It functions as an ER stress sensor/transducer, and following ER stress-induced proteolysis, it functions as a nuclear transcription factor via a cis-acting ER stress response element (ERSE) that is present in the promoters of genes encoding ER chaperones. This protein has been identified as a survival factor for quiescent but not proliferative squamous carcinoma cells. There have been conflicting reports about the association of polymorphisms in this gene with diabetes in different populations, but another polymorphism has been associated with increased plasma cholesterol levels. This gene is also thought to be a potential therapeutic target for cystic fibrosis.
CAS Number
9007-83-4
Structure Composition
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
ATF6; ACHM7; ATF6A
Swiss Prot
P18850
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human ATF6 (NP_031374.2) .
Conjugation
Unconjugated
Applications
WB, IF/ICC, IHC
Dilution
WB,1:500 - 1:2000|IF/ICC,1:50 - 1:100|IHC,1:50 - 1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
90-100KDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Polyclonal Antibodies
Host or Source
Rabbit

Related Products

CatalogName
MB9072ATF6 monoclonal antibody
MB11925ATF6 monoclonal antibody
PPL00689PDONR223-ATF6
BS45571-01ATF6 Recombinant Rabbit mAb
BS79823-01ATF3 polyclonal antibody
BZ16715-01ATF5 polyclonal antibody
BS6475ATF4 polyclonal antibody
BS76929-01ATF6B polyclonal antibody
BS77606-01ATF5 polyclonal antibody
BS90098ATF2 polyclonal antibody

Alternative Products

CatalogName
MBS2543091-01ATF6 Polyclonal Antibody
AF6243ATF6 Rabbit Polyclonal Antibody
NBP2-48501-25ulRabbit Polyclonal ATF6 Antibody
HB163034-01Anti-ATF6 Polyclonal Antibody
GWB-BBP032Polyclonal Anti-ATF6 Antibody

Popular Products