DTX2 polyclonal antibody

• Background :

  Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

• Structure Composition :

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative :

  Probable E3 ubiquitin-protein ligase DTX2; Protein deltex-2; Deltex2; hDTX2; RING finger protein 58; DTX2; KIAA1528; RNF58

• Swiss Prot :

  Q86UW9

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Recombinant full length Human DTX2.

• Conjugation :

  Unconjugated

• Applications :

  WB IHC

• Dilution :

  WB: 1:500~1:2000 IHC: 1:50~1:200

• Purity :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification :

  Unmodified

• Molecular Weight :

  ~ 67kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  DTX2 polyclonal antibody detects endogenous levels of DTX2 protein.

• Applications Notes :

  Western blot analysis of Deltex-2 expression in Jurkat (A), HepG2 (B), mouse testis (C), mouse spleen (D) whole cell lysates.

• Host or Source :

  Rabbit

• CAS Number :

  9007-83-4