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QPCT polyclonal antibody

CAT: 0384-BS8375-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS8375-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
QPCT (glutaminyl-peptide cyclotransferase) is a 361 amino acid protein that belongs to the glutaminyl-peptide cyclotransferase family. QPCT is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. QPCT binds one zinc ion per subunit and has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue. The human QPCT gene shares 86% overall sequence identity with the bovine homolog. QPCT contains an N-terminal signal peptide region, several glycosylation and phosphorylation sites and two cysteine residues conserved between the bovine and human enzymes. Existing as two alternatively spliced isoforms, the QPCT gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, fruit fly, mosquito, M.grisea and N.crassa, and maps to human chromosome 2p22.2.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Glutaminyl-peptide cyclotransferase; Glutaminyl cyclase; QC; sQC; Glutaminyl-tRNA cyclotransferase; Glutamyl cyclase; EC; QPCT
Swiss Prot
Q16769
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant full length Human QPCT.
Conjugation
Unconjugated
Applications
WB IF
Dilution
WB: 1:500~1:2000 IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 41 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
QPCT polyclonal antibody detects endogenous levels of QPCT protein.
Applications Notes
Western blot analysis of extracts of various cell lines, using QPCT antibody.
Host or Source
Rabbit

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