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LNX1 polyclonal antibody

CAT: 0384-BS8252-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS8252-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
LNX1 (Ligand of Numb Protein X1, LNX, PDZ DOMAIN-CONTAINING RING FINGER PROTEIN 2, PDZRN2) is a RING finger and PDZ domain containing protein that associates with Numb, a phosphotyrosine-binding (PTB) domain-containing protein that functions as a cell fate determinant. Studies indicate that the protein contains an N-terminal PTB domain-binding motif and 4 PDZ domains. Northern blot analysis has detected the expression of LNX1 in heart, placenta, kindney, pancreas and brain tissues. By radiation hybrid mapping, the LNX gene was localized to human chromosome 4q12 between marker D4S1577 and marker D4S1594. Research suggests that the presence of multiple protein binding domains involved in signal transduction and association with Numb and SKIP may suggest an important role for LNX in tumorogenesis.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
E3 ubiquitin-protein ligase LNX; Ligand of Numb-protein X 1; Numb-binding protein 1; PDZ domain-containing RING finger protein 2; LNX1; LNX; PDZRN2; UNQ574/PRO1136
Swiss Prot
Q8TBB1
Reactivity
Human
Immunogen
Recombinant full length Human LNX1.
Conjugation
Unconjugated
Applications
IF
Dilution
IF 1:50 - 1:100
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 81 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
LNX1 polyclonal antibody detects endogenous levels of LNX1 protein.
Applications Notes
Immunofluorescence analysis of U2OS cell using LNX1 antibody. Blue: DAPI for nuclear staining.
Host or Source
Rabbit

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