GPS2 polyclonal antibody

• Background :

  This gene encodes a protein involved in G protein-mitogen-activated protein kinase (MAPK) signaling cascades. When overexpressed in mammalian cells, this gene could potently suppress a RAS- and MAPK-mediated signal and interfere with JNK activity, suggesting that the function of this gene may be signal repression. The encoded protein is an integral subunit of the NCOR1-HDAC3 (nuclear receptor corepressor 1-histone deacetylase 3) complex, and it was shown that the complex inhibits JNK activation through this subunit and thus could potentially provide an alternative mechanism for hormone-mediated antagonism of AP1 (activator protein 1) function.

• Structure Composition :

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative :

  AMF-1

• Swiss Prot :

  Q13227

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  A synthetic peptide ofmouse GPS2

• Conjugation :

  Unconjugated

• Applications :

  WB

• Dilution :

  WB 1:500 - 1:2000

• Purity :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification :

  Unmodification

• Molecular Weight :

  37kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  GPS2 polyclonal antibody detects endogenous levels of GPS2 protein.

• Applications Notes :

  Western blot analysis of extracts of various cell lines, using GPS2 antibody.

• Host or Source :

  Rabbit

• CAS Number :

  9007-83-4