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MAX polyclonal antibody

CAT: 0384-BS6912-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS6912-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
It is now well established that the nature and relative abundance of individual subunits of different classes of transcription factors can positively or negatively regulate levels of gene expression. Myc proteins homodimerize and bind DNA poorly, if at all, at physiological levels. Max is a nuclear localized bHLH-Zip protein initially identified by screening a B cell expression library with the bHLH-Zip region of c-Myc. Max homodimers and the Myc-Max heterodimers bind the sequence CACGTG; however the binding of the hetero-dimeric complex is stronger than the Max homodimer. The Max gene products have been identified as Max and Max 9 proteins that differ by a 9 amino acid insertion N-terminal to the basic region. In contrast to Myc, which is highly regulated during progression through the cell cycle, Max is highly stable and is much more abundant than Myc. Two members of the bHLH-Zip protein family, designated Mad and Mxi1, homodimerize poorly but form heterodimeric complexes with Max that have opposing functions to Myc-Max heterodimers with respect to regulation of gene expression.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Protein max; Class D basic helix-loop-helix protein 4; bHLHd4; Myc-associated factor X; BHLHD4
Swiss Prot
P61244
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant full length Human MAX.
Conjugation
Unconjugated
Related Pathways
Signaling Pathways Activating p38 MAP Kinase
Applications
WB IHC IF
Dilution
WB: 1:500~1:2000 IHC/IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 18 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
MAX polyclonal antibody detects endogenous levels of MAX protein.
Applications Notes
Western blot analysis of extracts of HEK-293 cell lines, using MAX antibody.
Host or Source
Rabbit

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