HSPBAP1 polyclonal antibody

• Background :

  HSPBAP1 (HSPB (heat shock 27 kDa) associated protein 1), also known as PASS1 (protein associated with small stress protein 1), is a 488 amino acid cytoplasmic protein that contains one JMJC (Jumonji C) domain and shares 80% identity with its rat homolog, PASS1. Widely expressed with highest expression in ovary, thymus and pancreas, HSPBAP1 is thought to play a role in mediating cellular stress responses within the cell. Due to the presence of a JMJC domain, HSPBAP1 may be involved in chromatin remodeling events. Defects or translocations in the gene encoding HSPBAP1 are associated with renal cell carcinoma 1 (RCC1), suggesting a possible role for HSPBAP1 in carcinogenesis. Three isoforms of HSPBAP1 exist due to alternative splicing events.

• Structure Composition :

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative :

  HSPB1-associated protein 1; 27 kDa heat shock protein-associated protein 1; Protein associated with small stress protein 1; HSPBAP1; PASS1

• Swiss Prot :

  Q96EW2

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Synthetic peptide, corresponding to amino acids 330-380 of Human HSPBAP1.

• Conjugation :

  Unconjugated

• Applications :

  WB

• Dilution :

  WB: 1:500~1:1000

• Purity :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification :

  Unmodification

• Molecular Weight :

  ~ 55 kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  HSPBAP1 polyclonal antibody detects endogenous levels of HSPBAP1 protein.

• Applications Notes :

  Western blot (WB) analysis of HSPBAP1 polyclonal antibody at 1:500 dilution Lane1:CT26 whole cell lysate (40ug) Lane2:SGC7901 whole cell lysate (40ug) Lane3:HCT116 whole cell lysate (40ug) Lane4:C6 whole cell lysate (40ug) Lane5:PC12 whole cell lysate (40ug) Lane6:MCF-7 whole cell lysate (40ug) Lane7:A549 whole cell lysate (40ug)

• Host or Source :

  Rabbit

• CAS Number :

  9007-83-4