KANK2 polyclonal antibody

• Background :

  Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway (PubMed:24671081) . May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIFM1 to the nucleus (PubMed:22371500) . May be involved in promotion of cell proliferation (By similarity) .

• Structure Composition :

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative :

  KN motif and ankyrin repeat domain-containing protein 2; Ankyrin repeat domain-containing protein 25; Matrix-remodeling-associated protein 3; SRC-1-interacting protein; SIP; SRC-interacting protein; SRC1-interacting protein; KANK2; ANKRD25; KIAA1518; MXRA3; SIP

• Swiss Prot :

  Q63ZY3

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Synthetic peptide, corresponding to amino acids 340-385 of Human KANK2.

• Conjugation :

  Unconjugated

• Applications :

  WB

• Dilution :

  WB: 1:500~1:1000 IHC: 1:50~1:200

• Purity :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification :

  Unmodification

• Molecular Weight :

  ~ 117 kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  KANK2 polyclonal antibody detects endogenous levels of KANK2 protein.

• Applications Notes :

  Western blot (WB) analysis of KANK2 polyclonal antibody at 1:1000 dilution Lane1:HELA whole cell lysate (51.3μg) Lane2:The Uterus tissue lysate of Rat (43.4μg) Lane3:The Uterus tissue lysate of Mouse (37.4μg) Lane4:The Heart tissue lysate of Rat (43.4μg) Lane5:The Heart tissue lysate of Mouse (37.4μg)

• Host or Source :

  Rabbit

• CAS Number :

  9007-83-4