CSF2RA polyclonal antibody

• Background:

  The human IL-3, IL-5 and GM-CSF receptors are each composed of both unique a subunits and a common β subunit. The a subunits are low affinity ligand binding proteins while the β subunits do not themselves bind ligand, but are required for high affinity binding by the a subunits. In contrast, the mouse IL-3 receptor has two distinct β subunits, one that functions only in IL-3 mediated cell signaling and a second that is shared with IL-5 and GM-CSF. The murine β-subunits are 91% homologous at the amino acid level but only 56% homologous to the human β subunit. Although neither the murine nor the human β subunit contains tyrosine kinase domains, both activate tyrosine phosphorylation mediated signaling pathways.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative:

  Granulocyte-macrophage colony-stimulating factor receptor subunit alpha; GM-CSF-R-alpha; GMCSFR-alpha; GMR-alpha; CDw116; CD116; CSF2RA; CSF2R; CSF2RY

• Swiss Prot:

  P15509

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide corresponding to residues in Human CSF2RA.

• Conjugation:

  Unconjugated

• Applications:

  WB

• Dilution:

  WB: 1:500~1:1000

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  ~ 46 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  CSF2RA polyclonal antibody detects endogenous levels of CSF2RA protein.

• Applications Notes:

  Western blot (WB) analysis of CSF2RA polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:RAW264.7 whole cell lysate Lane3:H9C2 whole cell lysate

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4