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CD114/CSF3R polyclonal antibody

CAT: 0384-NCP0250P-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-NCP0250P-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Granulocyte colony-stimulating factor receptor (G-CSF-R) is a transmembrane protein comprised of an immunoglobulin-like (Ig-like) domain, a cytokine receptor-homologous (CRH) domain, and three fibronectin type III (FN III) domains. G-CSF-R is expressed on all granulocytic lineages, including progenitor cells, and has been detected on monocytes, T and B lymphocytes, as well as non-hematopoietic tissues including cardiomyocytes and neural stem cells. The primary ligand for G-CSF-R is the cytokine granulocyte colony-stimulating factor (G-CSF) . G-CSF-R has no intrinsic tyrosine kinase activity; ligand binding induces conformational changes in the receptor, leading to activation of the Jak/Stat, PI3K/Akt, and MAPK pathways. G-CSF induces differentiation and proliferation of myeloid progenitor cells into neutrophils. Multiple diseases have been associated with mutations of the G-CSF-R gene, CSF3R, including severe congenital neutropenia (SCN), chronic neutrophilic leukemia (CNL), and atypical chronic myeloid leukemia (aCML) .
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2.
Product Name Alternative
Granulocyte colony-stimulating factor receptor; G-CSF receptor; G-CSF-R; CD_antigen: CD114; CSF3R; GCSFR
Swiss Prot
Q99062
Reactivity
Human, Mouse
Immunogen
Recombinant protein of human CD114/CSF3R.
Conjugation
Unconjugated
Applications
WB IF
Dilution
WB: 1:1000~1:2000 IF 1:100 - 1:500
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodified
Molecular Weight
~ 105 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CD114/CSF3R polyclonal antibody detects endogenous levels of CD114/CSF3R protein.
Applications Notes
Western blot (WB) analysis of CD114/CSF3R polyclonal antibody at 1:1000 dilution Lane1:A549 whole cell lysate (30ug) Lane2:SP2/0 whole cell lysate (30ug) Lane3:The Brain tissue lysate of Mouse (30ug)
Host or Source
Rabbit

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