CDH23 polyclonal antibody

CAT: 0384-BS60676-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS60676-01Size:50 µL
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Background
Cadherin-23 represents the first in this family of calcium binding proteins of which mutations in the extracellular calcium binding domain contribute to an inherited disorder, Usher syndrome type 1D (USH1D) . Patients with USH1D exhibit congenital sensorineural hearing loss, vestibular dysfunction, and visual impairment due to early onset of retinitis pigmentosa (RP) . In the inner ear, cadherin-23 interacts with myosin VIIIa and harmonin to form a functional network duing hair cell differentiation, and in the retina to assemble a supra-molecular complex contributing to the organization of the cytoskeletal matrices of the pre- and post-synaptic region. A number of cadherin-23 splice variants exist in association with various phenotypic expression, indicating that differential mutations result in variable presentation of the disease.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Cadherin-23; Otocadherin; CDH23; KIAA1774; KIAA1812; UNQ1894; PRO4340
Swiss Prot
Q9H251
Reactivity
Human
Immunogen
A synthetic peptide corresponding to residues in Human CDH23
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 59 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
CDH23 polyclonal antibody detects endogenous levels of CDH23 protein.
Applications Notes
Western blot (WB) analysis of CDH23 polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate
Host or Source
Rabbit

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