MINA polyclonal antibody

• Background:

  Mina53, also known as MINA (MYC induced nuclear antigen), MDIG or NO52, is a 465 amino acid protein that contains one JmjC domain and localizes to the nucleus. Expressed in placenta, liver, heart, pancreas and skeletal muscle, Mina53 is thought to be involved in ribosome biogenesis, specifically in the assembly of pre-ribosomal particles. Via its involvement in ribosome biogenesis, Mina53 may play an important role in cell growth and survival, as well as overall cellular proliferation events. Mina53 expression is upregulated in esophageal squamous cell carcinoma (ESCC), colon cancer and lung cancer tissues, suggesting that Mina53 may be involved in tumorigenesis. Multiple isoforms of Mina53 exist due to alternative splicing events.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative:

  Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA; 60S ribosomal protein L27a histidine hydroxylase; Histone lysine demethylase MINA; MYC-induced nuclear antigen; Mineral dust-induced gene protein; Nucleolar protein 52; Ribosomal oxygenase MINA; ROX; MINA; MDIG; MINA53; NO52

• Swiss Prot:

  Q8IUF8

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide corresponding to residues in Human MINA.

• Conjugation:

  Unconjugated

• Applications:

  WB

• Dilution:

  WB: 1:500~1:1000

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  ~ 53 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  MINA polyclonal antibody detects endogenous levels of MINA protein.

• Applications Notes:

  Western blot (WB) analysis of MINA polyclonal antibody at 1:500 dilution Lane1:HEK293T whole cell lysate Lane2:NIH-3T3 whole cell lysate Lane3:PC12 whole cell lysate

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4