RECQL4 polyclonal antibody

CAT: 0384-BS60115-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS60115-01Size:50 µL
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Background
In humans, the RecQ helicase family includes WRN, BLM, RecQL1, RecQL4 and RecQL5 proteins, all of which contain a conserved helicase domain. WRN and BLM have been demonstrated to be the responsible genes in Werner and Bloom syndromes, respectively. RecQL1 and RecQL5 also belong to the human RecQ helicase family, but their correlation with genetic disorders, if any, is unknown. The gene encoding human RecQL4, which maps to chromosome 8q24.3, is believed to be the gene responsible for the development of Rothmund-Thomson syndrome (RTS) . The levels of WRN, BLM, RecQL1, 4 and 5 are differentially up-regulated to guarantee genomic stability in cells that are transformed or actively proliferating. In humans, RecQL1 and RecQL5 map to chromosome 12p12 and 17q25, respectively.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
ATP-dependent DNA helicase Q4; DNA helicase, RecQ-like type 4; RecQ4; RTS; RecQ protein-like 4; RECQ4
Swiss Prot
O94761
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to residues in Human RECQL4.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 133 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
RECQL4 polyclonal antibody detects endogenous levels of RECQL4 protein.
Applications Notes
Western blot (WB) analysis of RECQL4 polyclonal antibody at 1:500 dilution Lane1:Hela whole cell lysate Lane2:NIH-3T3 whole cell lysate Lane3:Rat brain tissue lysate
Host or Source
Rabbit

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