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Elf-4 polyclonal antibody

CAT: 0384-BS5710-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS5710-01Size:50 µL
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Background
The Ets-1 family of transcription factors has a conserved DNA binding domain through which it plays an important role in cellular proliferation, differentiation, tematopoiesis and angiogenesis. This domain, also known as the Ets domain, binds to DNA sequences containing the consensus sequence 5'-WGGA-3', which is known as the Ets-binding domain. Elf-4, also known as myeloid Elf-1-like factor, ELF4 or MEF, is a 663 amino acid member of the Ets-1 family. Localized to the nucleus, Elf-4 is highly expressed in placenta and myeloid leukemia cells, with lower levels of expression lung, heart, thymus, slpeen, colon, ovary and peripheral blood lymphocytes. Functioning primarily to activate the promoters of hematopoietic growth factor genes, such as GM-CSF, IL-3 and IL-8, Elf-4 has also been shown to activate the Perforin 1 promoter in natural killer (NK) cells, suggesting a possible role in tumorigenesis.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
ETS-related transcription factor Elf-4; E74-like factor 4; Myeloid Elf-1-like factor; ELF4; ELFR; MEF
Swiss Prot
Q99607
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 219-264 of Human Elf-4.
Conjugation
Unconjugated
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 71 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Elf-4 polyclonal antibody detects endogenous levels of Elf-4 protein.
Applications Notes
Western blot (WB) analysis of Elf-4 polyclonal antibody at 1:500 dilution Lane1:Hela cell lysate Lane2:Raw264.7 cell lysate Lane3:H9C2 cell lysate
Host or Source
Rabbit

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