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EIF2α (phospho-S51) polyclonal antibody

CAT: 0384-BS4787-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS4787-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
EIF2α, also known as EIF2S1 or EIF2, is a 315 amino acid subunit of the eukaryotic initiation complex that functions to bind tRNA to the 40S ribosomal subunit (in a GTP-dependent manner), thereby initiating translation. In addition, the phosphorylation state of eIF2α controls the rate of tRNA translation. When eIF2α is not phosphorylated, translation occurs at a normal rate. However, upon phosphorylation by one of several kinases, eIF2α is stabilized, thus preventing the GDP/GTP exchange reaction and slowing translation.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha; eIF-2-alpha; eIF-2A; eIF-2alpha; EIF2A; EIF2S1
Swiss Prot
P05198
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic phosphopeptide derived from human eIF2α around the phosphorylation site of Serine 51.
Conjugation
Unconjugated
Related Pathways
Translational Contral Regulation of elF2
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Phosphorylation
Molecular Weight
~ 38 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
P-eIF2α (S51) polyclonal antibody detects endogenous levels of eIF2αprotein only when phosphorylated at Ser51.
Applications Notes
Western blot (WB) analysis of p-eIF2α (S51) pAb at 1:500 dilution Lane1:Hela whole cell lysate (40ug) Lane2:MCF-7 whole cell lysate (40ug) Lane3:The Uterus tissue lysate of Rat (40ug) Lane4:The Lung tissue lysate of Mouse (40ug) Lane5:A2780 whole cell lysate (40ug) Lane6:H1792 whole cell lysate (40ug)
Host or Source
Rabbit

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