PD2R (E301) polyclonal antibody

CAT: 0384-BS3239-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0384-BS3239-01Size:50 µL
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Background
The prostaglandin D2 receptor is a member of the G-protein-coupled receptor (GPCR) family (subfamily: prostanoid) . It has been shown to function as a prostanoid DP receptor. Its activity is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca2+. Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D2 (PGD2), functions as a mast cell-derived mediator to trigger asthmatic responses. Prostaglandin D2 receptor has been reported to be expressed in human small intestine, colon (goblet cells), eye, and eosinophils. ESTs have been isolated from human brain libraries.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Prostaglandin D2 receptor; PGD receptor; PGD2 receptor; Prostanoid DP receptor; PTGDR
Swiss Prot
Q13258
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 271-321 of Human PD2R.
Conjugation
Unconjugated
Applications
WB IF
Dilution
WB: 1:500~1:1000 IF: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 40 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
PD2R (E301) polyclonal antibody detects endogenous levels of PD2R protein.
Applications Notes
Western blot (WB) analysis of PD2R (E301) pAb at 1:1000 dilution Lane1:The Eye tissue lysate of Mouse (40ug) Lane2:The Eye tissue lysate of Rat (40ug) Lane3:HCT116 whole cell lysate (40ug) Lane4:HEK293T whole cell lysate (40ug)
Host or Source
Rabbit

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