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ALOX5 (E267) polyclonal antibody

CAT: 0384-BS1506-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS1506-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
5-lipoxygenase (5-LO) is expressed primarily in polymorphonuclear leukocytes, macrophages, and mast cells. 5-LO performs the first two catalytic reactions in the biosynthesis of leukotrienes, lipid metabolites that induce contractions of airway smooth muscle and increase vascular permeability during anaphylaxis. The cellular localization of 5-LO varies between cell types. In activated blood polymorphonuclear leukocytes 5-LO undergoes calcium dependent translocation from the cytosol to the nuclear envelope. In alveolar macrophages, the majority of 5-LO is localized in the nucleus and, upon activation of these cells, intranuclear 5-LO binds to the nuclear membrane.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Arachidonate 5-lipoxygenase; 5-LO; 5-lipoxygenase; ALOX5; LOG5
Swiss Prot
P09917
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 231-280 of Human ALOX5.
Conjugation
Unconjugated
Applications
IHC
Dilution
IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 78 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
ALOX5 (E267) polyclonal antibody detects endogenous levels of ALOX5 protein.
Host or Source
Rabbit

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