Products for Research Use Only
RegisterLogin

ALOX15 polyclonal antibody

CAT: 0384-BS80489-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0384-BS80489-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. It inserts peroxyl groups at C12 or C15 of arachidonate ((5Z,8Z,11Z,14Z-eicosatetraenoate producing both 12-hydroperoxyeicosatetraenoate/12-HPETE and 15-hydroperoxyeicosatetraenoate/15-HPETE. It may then act on 12-HPETE to produce hepoxilins, which may show proinflammatory properties (By similarity. Can also peroxidize linoleate ((9Z,12Z-octadecadienoate to 13-hydroperoxyoctadecadienoate/13-HPODE. May participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoate to generate specialized pro-resolving mediators (SPMslike resolvin D5 ((7S,17S-diHPDHA and (7S,14S-diHPDHA, that actively downregulate the immune response and have anti-aggregation properties with platelets. Can convert epoxy fatty acids to hydroperoxy-epoxides derivatives followed by an intramolecular nucleophilic substitution leading to the formation of monocyclic endoperoxides. Plays an important role during the maintenance of self-tolerance by peroxidizing membrane-bound phosphatidylethanolamine which can then signal the sorting process for clearance of apoptotic cells during inflammation and prevent an autoimmune response.
CAS Number
9007-83-4
Structure Composition
1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
ALOX15;12-LOX;15-LOX-1;15LOX-1
Swiss Prot
P16050
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein of human ALOX15 (NP_001131.3) .
Conjugation
Unconjugated
Applications
IHC, IF/ICC
Dilution
IHC,1:50 - 1:200|IF/ICC,1:50 - 1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
Refer to figures
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Unmodification
Applications Notes
Immunohistochemistry of paraffin-embedded mouse intestin using ALOX15 Rabbit pAb at dilution of 1:25 .Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.
Host or Source
Rabbit

Related Products

CatalogName
BS47346-01ALOX15 Recombinant Rabbit mAb
BS8548-01ALOX15B polyclonal antibody
BS65873ALOX12 Polyclonal Antibody
BS75907-01ALOX12 polyclonal antibody
BS6913-01ALOX5 polyclonal antibody
BS1506-01ALOX5 (E267) polyclonal antibody
BS71134-01ALOXE3 polyclonal antibody
BS74009-01Phospho-ALOX5-S271 polyclonal antibody
BZ16794-01Polyclonal antibodyPN1 polyclonal antibody
BS75206-01AaaaaASPH polyclonal antibody

Alternative Products

CatalogName
MBS2525388-01ALOX15 Polyclonal Antibody
MBS2538770-01ALOX15 Polyclonal Antibody
HB614014-01Anti-ALOX15 Polyclonal Antibody
TA354512ALOX15 Rabbit Polyclonal Antibody
TA305627ALOX15 Goat Polyclonal Antibody

Popular Products