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Integrin β5 (V746) polyclonal antibody

CAT: 0384-BS1188-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS1188-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Integrins are heterodimers composed of noncovalently associated transmembrane α and β subunits. The 16α and 8β subunits heterodimerize to produce more than 20 different receptors. Most Integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain Integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster Integrins by binding to adjacent Integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of Integrinmediated responses. In addition to mediating cell adhesion and cytoskeletal organization, Integrins function as signaling receptors. Signals transduced by Integrins play a role in many , biological processes, including cell growth, differentiation, migration and apoptosis.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Integrin beta-5; ITGB5
Swiss Prot
P18084
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to amino acids 720-770 of Human Integrin β5.
Conjugation
Unconjugated
Related Pathways
Regulation of Actin Dynamics, Tumor Angiogenesis
Applications
WB
Dilution
WB: 1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 100 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
Integrin β5 (V746) polyclonal antibody detects endogenous levels of Integrin β5 protein.
Applications Notes
Western blot (WB) analysis of Integrin β5 polyclonal antibody at 1:500 dillution Lane1:MCF-7 whole cell lysate (40μg) Lane2:LO2 whole cell lysate (40μg) Lane3:CT-26 whole cell lysate (40μg) Lane4:H9C2 whole cell lysate (40μg)
Host or Source
Rabbit

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