CD2AP polyclonal antibody

• Background:

  This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative:

  CMS; CD2-associated protein; Adapter protein CMS

• Swiss Prot:

  Q9Y5K6

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  A synthetic peptide of human CD2AP.

• Conjugation:

  Unconjugated

• Related Pathways:

  Contribution of ECM and Cytoskeletal Factors to EMT, Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease

• Applications:

  WB

• Dilution:

  WB 1:500 - 1:2000

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  ~ 90 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  CD2AP polyclonal antibody detects endogenous levels of CD2AP protein.

• Applications Notes:

  Western blot analysis of extracts of various cells, using CD2AP antibody.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4