CDK2AP1 polyclonal antibody

• Background:

  The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

• Structure Composition:

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative:

  DOC1; ST19; DORC1; doc-1; p12DOC-1

• Swiss Prot:

  O14519

• Reactivity:

  Human

• Immunogen:

  A synthetic peptide of human CDK2AP1

• Conjugation:

  Unconjugated

• Applications:

  WB

• Dilution:

  WB 1:200 - 1:1000

• Purity:

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification:

  Unmodification

• Molecular Weight:

  ~ 13 kDa

• Storage Conditions:

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes:

  For research use only, not for use in diagnostic procedure.

• Specificity:

  CDK2AP1 polyclonal antibody detects endogenous levels of CDK2AP1 protein.

• Applications Notes:

  Western blot analysis of CDK2AP1 antibody.

• Host or Source:

  Rabbit

• CAS Number:

  9007-83-4