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ADAM10 polyclonal antibody

CAT: 0384-BS62556-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS62556-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ADAM (a disintegrin and metalloprotease) proteins are a family of over 30 membrane-anchored, glycosylated, Zn2+ dependent proteases that are involved in cell-cell, cell-matrix interface related processes including fertilization, muscle fusion, secretion of TNFα (tumor necrosis factor α), and modulation of the neurogenic function of Notch and Delta. ADAM proteins possess a signal-domain, a pro-domain, a metalloprotease domain, a disintegrin domain (integrin ligand) a cysteine-rich region, an epidermal growth factor-like domain, a transmembrane domain and a cytoplasmic tail. ADAMs are expressed in brain, testis, epididymis, ovary, breast, placenta, liver, heart, lung, bone and muscle, and catalyze proteolysis, adhesion, fusion and intracellular signaling. ADAM10 is a TNF-processing enzyme that cleaves pro-TNF, a membrane-bound precusor protein, at Ala 76-Val 77, which causes membrane shedding of soluble TNF.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
RAK; kuz; AD10; AD18; MADM; CD156c; HsT18717
Swiss Prot
O14672
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to Human ADAM10.
Conjugation
Unconjugated
Related Pathways
Notch Signaling
Applications
WB IHC
Dilution
WB:1:500~1:1000 IHC:1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 90 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
ADAM10 polyclonal antibody detects endogenous levels of ADAM10 protein.
Applications Notes
Western blot (WB) analysis of ADAM10 polyclonal antibody at 1:500 dilution LaneA:HepG2 whole cell lysate LaneB:U-87MG whole cell lysate LaneC:A549 whole cell lysate LaneD:SP2/0 whole cell lysate LaneE:PC12 whole cell lysate
Host or Source
Rabbit

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