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ADAM19 polyclonal antibody

CAT: 0384-BS60747-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS60747-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The ADAM (a disintegrin and metalloprotease) protein family, which includes over 30 membrane-anchored, glycosylated, Zn2+ dependent proteases, plays a role in cell-cell and cell-matrix interface related processes, including fertilization, muscle fusion, secretion of TNFα (tumor necrosis factor α), and modulation of the neurogenic function of Notch and Delta. The ADAM proteins possess a signal-domain, a pro-domain, a metalloprotease domain, a disintegrin domain (Integrin ligand), a cysteine-rich region, an epidermal growth factor-like domain, a transmembrane domain and a cytoplasmic tail. ADAMs are expressed in a wide range of mammalian tissues and several are abundantly expressed in the male reproductive tract . Expression of ADAM19, also designated meltrin b, is highest in the peripheral nervous system during embryogenesis, but is also apparent in placenta, brain, heart, lung, leukocytes, and SW480 cells . ADAM19 also serves as a dendritic cell marker. Truncation of ADAM19 in its cysteine-rich domain is necessary to exert its proteolytic activity on specific substrates, including a2-macroglobulin .
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
Disintegrin and metalloproteinase domain-containing protein 19; ADAM 19; Meltrin-beta; Metalloprotease and disintegrin dendritic antigen marker; MADDAM; ADAM19; MLTNB; FKSG34
Swiss Prot
Q9H013
Reactivity
Human
Immunogen
A synthetic peptide corresponding to residues in Human ADAM19
Conjugation
Unconjugated
Applications
WB IHC
Dilution
WB: 1:500~1:1000 IHC: 1:50~1:200
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 105 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
ADAM19 polyclonal antibody detects endogenous levels of ADAM19 protein.
Applications Notes
Western blot (WB) analysis of ADAM19 polyclonal antibody at 1:500 dilution Lane1:MCF-7 whole cell lysate
Host or Source
Rabbit

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