MNK2 polyclonal antibody

• Background :

  The MAPKAP kinases (for MAP kinase activated protein kinases) are a group of MAP kinase substrates which are themselves kinases. In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif. Several kinases that contain this motif have been identifed and serve as substrates for the ERK and p38 MAP kinases. These include the serine/threonine kinases Rsk-1 (also designated MAPKAP kinase-1), Rsk-2 and Rsk-3, which are phosphorylated by ERK1 and ERK2. Similarly, p38 phosphorylates and activates the serine/threonine kinases MAPKAP kinase-2 and MAPKAP kinase-3 (also designated 3pK) . The serine/ threonine kinases Mnk1 and Mnk2 are substrates for both ERK and p38 MAP kinases. Mnk2 exists as multiple isoforms, including Mnk2a and Mnk2b, due to alternative splicing events.

• Structure Composition :

  Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

• Product Name Alternative :

  MAP kinase-interacting serine/threonine-protein kinase 2; MAP kinase signal-integrating kinase 2; MAPK signal-integrating kinase 2; Mnk2; MKNK2; GPRK7; MNK2

• Swiss Prot :

  Q9HBH9

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Synthetic peptide, corresponding to Human MNK2.

• Conjugation :

  Unconjugated

• Related Pathways :

  Signaling Pathways Activating p38 MAP Kinase

• Applications :

  WB

• Dilution :

  WB:1:500~1:1000

• Purity :

  The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

• Modification :

  Unmodification

• Molecular Weight :

  ~ 52 kDa

• Storage Conditions :

  Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

• Notes :

  For research use only, not for use in diagnostic procedure.

• Specificity :

  MNK2 polyclonal antibody detects endogenous levels of MNK2 protein.

• Applications Notes :

  Western blot (WB) analysis of Cyclin E1 polyclonal antibody at 1:500 dilution LaneA:SGC7901 whole cell lysate LaneB:PC3 whole cell lysate LaneC:Jurkat whole cell lysate LaneD:The Eye tissue lysate of Mouse LaneE:The Brain tissue lysate of Rat

• Host or Source :

  Rabbit

• CAS Number :

  9007-83-4