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MNK2 polyclonal antibody

CAT: 0384-BS62248-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0384-BS62248-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The MAPKAP kinases (for MAP kinase activated protein kinases) are a group of MAP kinase substrates which are themselves kinases. In response to activation, the MAP kinases phosphorylate downstream components on a consensus Pro-X-Ser/Thr-Pro motif. Several kinases that contain this motif have been identifed and serve as substrates for the ERK and p38 MAP kinases. These include the serine/threonine kinases Rsk-1 (also designated MAPKAP kinase-1), Rsk-2 and Rsk-3, which are phosphorylated by ERK1 and ERK2. Similarly, p38 phosphorylates and activates the serine/threonine kinases MAPKAP kinase-2 and MAPKAP kinase-3 (also designated 3pK) . The serine/ threonine kinases Mnk1 and Mnk2 are substrates for both ERK and p38 MAP kinases. Mnk2 exists as multiple isoforms, including Mnk2a and Mnk2b, due to alternative splicing events.
CAS Number
9007-83-4
Structure Composition
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Product Name Alternative
MAP kinase-interacting serine/threonine-protein kinase 2; MAP kinase signal-integrating kinase 2; MAPK signal-integrating kinase 2; Mnk2; MKNK2; GPRK7; MNK2
Swiss Prot
Q9HBH9
Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide, corresponding to Human MNK2.
Conjugation
Unconjugated
Related Pathways
Signaling Pathways Activating p38 MAP Kinase
Applications
WB
Dilution
WB:1:500~1:1000
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Modification
Unmodification
Molecular Weight
~ 52 kDa
Storage Conditions
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Notes
For research use only, not for use in diagnostic procedure.
Specificity
MNK2 polyclonal antibody detects endogenous levels of MNK2 protein.
Applications Notes
Western blot (WB) analysis of Cyclin E1 polyclonal antibody at 1:500 dilution LaneA:SGC7901 whole cell lysate LaneB:PC3 whole cell lysate LaneC:Jurkat whole cell lysate LaneD:The Eye tissue lysate of Mouse LaneE:The Brain tissue lysate of Rat
Host or Source
Rabbit